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美开发新药物可阻止前列腺癌细胞扩散

发布时间:2012/4/29 8:00:40    发布者:中国中西医结合医学会    点击量:1083

 

近日,美国西北大学范伯格医学院研究人员发表研究报告说,经动物实验验证,他们开发的一种新药物不但能有效阻止前列腺癌细胞向其他身体组织扩散,而且无毒无副作用。

研究人员当天在芝加哥举行的美国癌症研究协会年会上介绍说,这种名为KBU2046的药物可绑定那些指示前列腺癌细胞转移的蛋白质,阻止癌细胞扩散。为验证它的药效,研究人员在小鼠体内植入恶性前列腺癌细胞,然后给它们喂食新药物,经过5周的观察,他们发现,癌细胞的扩散得到抑制,没有转移到肺部。

在实验鼠以及正常人类细胞上进行毒性研究后,研究人员还发现,KBU2046无毒且不会产生有害的副作用。研究人员说,他们下一步将开展相关的临床试验。

范伯格医学院教授雷蒙德·伯根说,癌细胞转移往往导致前列腺癌患者死亡,癌细胞内部拥有一个“开关”,可控制这些细胞的转移,KBU2046被证实能关闭这个“开关”,因而是一种非常有潜力的新药物。(生物谷Bioon.com)

New Drug Halts the Spread of Human Prostate Cancer Cells

by Marla Paul on Apr 03, 2012

A new drug developed by Northwestern Medicine® scientists prevented human prostate cancer cells from spreading to other tissues without any toxic effects to normal cells or tissues. The drug turns off the “go” switch in the cancer cells and immobilizes them. Prostate cancer is the second-leading cause of cancer death in North American males. Death is mainly caused by metastasis, prostate cancer cells moving out of prostate tissue and spreading to other organs. “This is an extremely promising new therapeutic that locks down aggressive prostate cancer cells so they don’t move,” said Raymond Bergan, MD, director of experimental therapeutics for the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. “The spread of prostate cancer is what kills men. Cancer cells have a switch that tells them to keep moving all the time. This drug turns it off.” The drug works by binding to and disabling proteins in the cancer cell that instruct it to move, said Bergan, a professor of medicine at Northwestern University Feinberg School of Medicine and a physician at Northwestern Memorial Hospital. The research was presented April 3 at the American Association for Cancer Research Annual Meeting 2012 in Chicago by Li Xu, MD, PhD, a research assistant professor of medicine at the medical school. She helped develop the drug, along with Karl Scheidt, PhD, an associate professor of chemistry at the Weinberg College of Arts and Sciences. In the study, Northwestern researchers transplanted aggressive human prostate cancer cells into mice prostate tissue and fed the mice with the new drug for five weeks. The drug inhibited movement of the cells and prevented them from metastasizing to the lung, one of the tissues to which prostate cancer spreads in men. Xu said she conducted extensive toxicity studies, including on normal human cells, and found that the drug, called KBU2046, is nontoxic and does not cause any harmful effects. “We envision that this drug, if shown to be effective in clinical trials, could be used to treat men diagnosed with prostate cancer, so they wouldn’t need more aggressive procedures,” Bergan said. “Or, the drug could augment the effectiveness of surgery and radiation.” Bergan hopes to test the drug in a clinical trial.