美开发新药物可阻止前列腺癌细胞扩散
近日,美国西北大学范伯格医学院研究人员发表研究报告说,经动物实验验证,他们开发的一种新药物不但能有效阻止前列腺癌细胞向其他身体组织扩散,而且无毒无副作用。
研究人员当天在芝加哥举行的美国癌症研究协会年会上介绍说,这种名为KBU2046的药物可绑定那些指示前列腺癌细胞转移的蛋白质,阻止癌细胞扩散。为验证它的药效,研究人员在小鼠体内植入恶性前列腺癌细胞,然后给它们喂食新药物,经过5周的观察,他们发现,癌细胞的扩散得到抑制,没有转移到肺部。
在实验鼠以及正常人类细胞上进行毒性研究后,研究人员还发现,KBU2046无毒且不会产生有害的副作用。研究人员说,他们下一步将开展相关的临床试验。
范伯格医学院教授雷蒙德·伯根说,癌细胞转移往往导致前列腺癌患者死亡,癌细胞内部拥有一个“开关”,可控制这些细胞的转移,KBU2046被证实能关闭这个“开关”,因而是一种非常有潜力的新药物。(生物谷Bioon.com)
New Drug Halts the Spread of Human Prostate Cancer Cells
by Marla Paul on Apr 03, 2012
A new drug developed by Northwestern Medicine® scientists prevented human prostate cancer cells from spreading to other tissues without any toxic effects to normal cells or tissues. The drug turns off the “go” switch in the cancer cells and immobilizes them. Prostate cancer is the second-leading cause of cancer death in North American males. Death is mainly caused by metastasis, prostate cancer cells moving out of prostate tissue and spreading to other organs. “This is an extremely promising new therapeutic that locks down aggressive prostate cancer cells so they don’t move,” said Raymond Bergan, MD, director of experimental therapeutics for the Robert H. Lurie Comprehensive Cancer Center of Northwestern University. “The spread of prostate cancer is what kills men. Cancer cells have a switch that tells them to keep moving all the time. This drug turns it off.” The drug works by binding to and disabling proteins in the cancer cell that instruct it to move, said Bergan, a professor of medicine at Northwestern University Feinberg School of Medicine and a physician at Northwestern Memorial Hospital. The research was presented April 3 at the American Association for Cancer Research Annual Meeting 2012 in Chicago by Li Xu, MD, PhD, a research assistant professor of medicine at the medical school. She helped develop the drug, along with Karl Scheidt, PhD, an associate professor of chemistry at the Weinberg College of Arts and Sciences. In the study, Northwestern researchers transplanted aggressive human prostate cancer cells into mice prostate tissue and fed the mice with the new drug for five weeks. The drug inhibited movement of the cells and prevented them from metastasizing to the lung, one of the tissues to which prostate cancer spreads in men. Xu said she conducted extensive toxicity studies, including on normal human cells, and found that the drug, called KBU2046, is nontoxic and does not cause any harmful effects. “We envision that this drug, if shown to be effective in clinical trials, could be used to treat men diagnosed with prostate cancer, so they wouldn’t need more aggressive procedures,” Bergan said. “Or, the drug could augment the effectiveness of surgery and radiation.” Bergan hopes to test the drug in a clinical trial.
- 自闭症的治疗研究进展——携手守护“星星的孩子”
- 卫立辛:肿瘤发生发展本质的认识
- 病毒载体治疗脑癌
- 全球首例母体内胎儿肺部手术成功
- 台科研新发现:注射心脏干细胞可修补心肌
- 干细胞疗法治疗心脏病取得重大突破
- 病毒载体治疗脑癌
- 我国建成世界最大人胚胎干细胞库
- 超级计算机将在单个细胞尺度精确模拟“人脑
- 美国批准阿尔茨海默氏症测试新法
- 德国科学家发现利用纳米微粒观察蛋白质分子运动新方法
- 美开发新药物可阻止前列腺癌细胞扩散
- 科学家将从干细胞中提炼卵子 女性或告别绝经期
- 运动中的头部创伤何时导致记忆丧失?
- 绝经女性每日吃海藻增患甲状腺癌风险
- DNA标记能指示卵巢癌治疗是否成功
- 新研究使癌细胞“发光” 发现胃癌转移病灶